https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44367 Wed 12 Oct 2022 10:10:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11847 Wed 11 Apr 2018 15:51:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22361 Wed 11 Apr 2018 15:08:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26931 Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.]]> Wed 11 Apr 2018 14:54:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22580 Wed 11 Apr 2018 14:49:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21035 Wed 11 Apr 2018 11:06:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10149 Sat 24 Mar 2018 10:31:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11540 Sat 24 Mar 2018 08:14:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20934 Sat 24 Mar 2018 08:06:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27971 0.05) influenced by time and temperature, compared with controls. Drying conditions of 65°C for 120 min are recommended for optimization of drying.]]> Sat 24 Mar 2018 07:38:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33951 Fri 25 Jan 2019 09:20:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33067 Sargassum vestitum, Sargassum linearifolium, Phyllospora comosa, Padina sp., Hormosira banksii and Sargassum podocanthum, were investigated for the chemical profile and antioxidant activity. The results showed that the extracts H. banksii, S. vestitum and Padina sp. indicated the significantly higher total phenolic compound (TPC) and antioxidant activities (ABTS, DPPH and FRAP) compared to the other species (P < 0.05) and comparable to positive controls: butylated hydroxytoluene, ascorbic acid and alpha‐tocopherol at the concentrations (0.06–1 mg mL−1). Fucoxanthin was also found in six species and isolated for evaluating antioxidant activity. In addition, the phenolic compounds were mainly responsible for antioxidant activity of the extracts, while fucoxanthin showed quite high antioxidant activity. It is suggested that S. vestitum, H. banksii and Padina sp. have the potent for extracting bioactive components and further applications in food and pharmaceutical industries.]]> Fri 24 Aug 2018 13:45:12 AEST ]]>